abstract：:Endothelial dysfunction is pivotal in atherosclerosis. Endothelial progenitor cells (EPC) predict cardiovascular events and could serve as a cellular biomarker of endothelial function. Epidemiological studies suggest the benefits of omega 3 polyunsaturated fatty acids (n-3 PUFA), mainly docosahexaenoic acid (DHA) and ...

journal_title：Atherosclerosis

authors： Devaraj S,Chien A,Rao B,Chen X,Jialal I

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVE:The benefits of fish oil fatty acids eicosapentaenoic (EPA) and docosahexaenoic acids (DHA) on plasma lipid profiles have been inconsistent but may partially depend on individual Apolipoprotein E (APOE) genotypes. We aimed to determine whether APOE genotype modifies the association of lipid profile characteri...

journal_title：Atherosclerosis

authors： Liang S,Steffen LM,Steffen BT,Guan W,Weir NL,Rich SS,Manichaikul A,Vargas JD,Tsai MY

更新日期：2013-05-01 00:00:00

abstract：:It is still controversial whether circulating soluble form of receptor for AGE (sRAGE) is associated with atherosclerosis in diabetic patients. In this study, we enrolled 276 Japanese type 2 diabetic subjects without history of cardiovascular disease (CVD), assessed their baseline clinical and biochemical data includi...

journal_title：Atherosclerosis

authors： Fujisawa K,Katakami N,Kaneto H,Naka T,Takahara M,Sakamoto F,Irie Y,Miyashita K,Kubo F,Yasuda T,Matsuoka TA,Shimomura I

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVE:Blood glucose fluctuations have been found to be relevant to the progression of atherosclerosis in patients with type 2 diabetes and to be more detrimental for the development of atherosclerosis than the sustained hyperglycemia. We aim at evaluating the effect of blunted daily acute glucose fluctuations by DP...

journal_title：Atherosclerosis

authors： Barbieri M,Rizzo MR,Marfella R,Boccardi V,Esposito A,Pansini A,Paolisso G

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVE:A direct correlation between blood glucose levels and the microvascular complications of diabetes is well established. However, the effects of hyperglycaemia on the vasa vasorum, a microvascular network which surrounds and supplies the walls of large arteries, is not known. The objective of this study is to i...

journal_title：Atherosclerosis

authors： Veerman KJ,Venegas-Pino DE,Shi Y,Khan MI,Gerstein HC,Werstuck GH

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Serum γ-glutamyl transferase (GGT) levels are known to be positively associated with obesity. We aimed at verifying an association between baseline GGT levels and the development of obesity in Korean men. PATIENTS AND METHODS:This prospective cohort study was performed on 18,510 initially non-...

journal_title：Atherosclerosis

authors： Suh YJ,Park SK,Choi JM,Ryoo JH

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVE:Pravastatin has been reported to elevate circulating adiponectin levels in patients with various insulin resistant state, hypertension, coronary artery disease, and hypercholesterolemia. This study aimed to evaluate whether pravastatin increase serum total and high molecular weight adiponectin levels and impr...

journal_title：Atherosclerosis

authors： Kim JH,Lee MR,Shin JA,Lee SS,Lee JM,You SJ,Yoon KH,Chang SA

更新日期：2013-04-01 00:00:00

abstract：:The negative correlation between percent flow-mediated dilation (FMD%) and baseline diameter (D(base)) has only recently been recognised as a fundamental ratio-scaling problem, which is not resolved by significance-testing of D(base) inequality between groups/conditions, nor by covariate-adjusting FMD% itself by D(bas...

journal_title：Atherosclerosis

authors： Atkinson G,Batterham AM

更新日期：2013-02-01 00:00:00

abstract：:The ATP-binding cassette transporter G1 (ABCG1) plays an important role in reverse cholesterol transport by exporting cholesterol to high density lipoproteins (HDL). Two major ABCG1 isoforms exist in humans, which differ by the presence or absence of twelve amino acids between the ATP cassette and the transmembrane do...

journal_title：Atherosclerosis

authors： Burns V,Sharpe LJ,Gelissen IC,Brown AJ

更新日期：2013-02-01 00:00:00

abstract：OBJECTIVE:Postprandial lipemia influences the development of atherosclerosis. Age has been defined as a regulating factor of the extent of postprandial lipemia, but its independence of other age-associated phenotypic features, such as metabolic syndrome, has not been fully elucidated. METHODS:To investigate if age is ...

journal_title：Atherosclerosis

authors： Perez-Caballero AI,Alcala-Diaz JF,Perez-Martinez P,Garcia-Rios A,Delgado-Casado N,Marin C,Yubero-Serrano E,Camargo A,Caballero J,Malagon MM,Tinahones FJ,Perez-Jimenez F,Lopez-Miranda J,Delgado-Lista J

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Matrix metalloproteinases (MMPs) have been implicated in development of atherosclerosis. MMPs are activated in patients with acute coronary syndrome (ACS). However, little data exist regarding the correlation between circulating levels of MMPs and plaque volume (PV) in patients with ACS. We therefore evaluat...

journal_title：Atherosclerosis

authors： Ogita M,Miyauchi K,Morimoto T,Daida H,Kimura T,Hiro T,Nakagawa Y,Yamagishi M,Ozaki Y,Matsuzaki M

更新日期：2013-01-01 00:00:00

abstract：:Research has indicated that inflammation promote all phases of atherosclerosis. The current study tested the hypothesis that rhinosinusitis is a risk marker for myocardial infarction (MI). Data on the general population were obtained from the Taiwan Longitudinal Health Insurance Database 2005 (LHID2005). The study coh...

journal_title：Atherosclerosis

authors： Hao WR,Lin HW,Chao PZ,Wu CW,Yen TH,Liu JC,Liou TH

更新日期：2013-01-01 00:00:00

abstract：AIMS:This study was set up to compare the accuracy, sensitivity and specificity of gene expression results between the Illumina HumanHT-12 v3 Expression BeadChip (GWE) and the TaqMan qRT-PCR low-density array (LDA) in atherosclerotic plaques. METHODS:Gene expression levels of 196 genes were determined from 22 atherosc...

journal_title：Atherosclerosis

authors： Raitoharju E,Seppälä I,Lyytikäinen LP,Levula M,Oksala N,Klopp N,Illig T,Laaksonen R,Kähönen M,Lehtimäki T

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVES:To examine whether serum concentrations of carotenoids are related to the risk of sudden cardiac death (SCD) in middle-aged men. METHODS:The study population consisted of 1031 Finnish men aged 46-65 years of the Kuopio Ischemic Heart Disease Risk Factor (KIHD) cohort. Serum concentrations of carotenoids wer...

journal_title：Atherosclerosis

authors： Karppi J,Laukkanen JA,Mäkikallio TH,Ronkainen K,Kurl S

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:CD36 signal transductions have been reported by a variety of lipid moiety of oxidized low-density lipoprotein (oxLDL), however, CD36 signal induced by 7-ketocholesteryl-9-carboxynonanoate (oxLig-1), a lipid moiety of oxLDL has not been elucidated. METHODS AND RESULTS:OxLig-1 leads to activation and recruitm...

journal_title：Atherosclerosis

authors： Li W,Wang D,Chi Y,Wang R,Zhang F,Ma G,Chen Z,Li J,Liu Z,Matsuura E,Liu Q

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:Atherosclerosis is an inflammatory process resulting from the interaction between genetic and environmental factors. Leukotrienes are inflammatory mediators generated from arachidonic acid, and genetic polymorphisms involved in leukotriene metabolism are implicated in atherosclerosis. The objectives of this s...

journal_title：Atherosclerosis

authors： Zhao J,Goldberg J,Vaccarino V

更新日期：2013-01-01 00:00:00

abstract：:The aim of this study is to assess the relationship of epicardial adipose tissue (EAT) and plaque vulnerability. We consecutively enrolled 82 patients with coronary artery disease (CAD). A symptom-related vessel was imaged by virtual histology intravascular ultrasound (VH-IVUS). In 60 out of 82 patients, all three ves...

journal_title：Atherosclerosis

authors： Park JS,Choi SY,Zheng M,Yang HM,Lim HS,Choi BJ,Yoon MH,Hwang GS,Tahk SJ,Shin JH

更新日期：2013-01-01 00:00:00

abstract：:Angiotensin converting enzyme 2 (ACE2) is a homolog of angiotensin converting enzyme (ACE) which generates angiotensin II from angiotensin I. ACE, its product angiotensin II and the downstream angiotensin type I receptor are important components of the renin-angiotensin system (RAS). Angiotensin II, the most important...

journal_title：Atherosclerosis

authors： Wang Y,Tikellis C,Thomas MC,Golledge J

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:Statins inhibit cholesterol synthesis but can upregulate cholesterol absorption, with higher doses producing larger effects. Ezetimibe inhibits cholesterol absorption but also upregulates synthesis. We tested whether ezetimibe added to on-going statin therapy would be most effective in lowering LDL-cholestero...

journal_title：Atherosclerosis

authors： Thongtang N,Lin J,Schaefer EJ,Lowe RS,Tomassini JE,Shah AK,Tershakovec AM

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVE:Lipoprotein(a) [Lp(a)] consists of apolipoprotein B-100 (apoB-100) as part of an LDL-like particle and the covalently linked glycoprotein apolipoprotein(a) [apo(a)]. Detailed mechanisms of its biosynthesis, assembly, secretion and catabolism are still poorly understood. To address the Lp(a) assembly mechanism...

journal_title：Atherosclerosis

authors： Frischmann ME,Ikewaki K,Trenkwalder E,Lamina C,Dieplinger B,Soufi M,Schweer H,Schaefer JR,König P,Kronenberg F,Dieplinger H

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:The CHA(2)DS(2)-VASc (congestive heart failure, hypertension, age ≥ 75 years (doubled), type 2 diabetes, previous stroke, transient ischemic attack, or thromboembolism (doubled), vascular disease, age 65-75 years, and sex category) score was published as a predictive scoring model for stroke in atrial fibril...

journal_title：Atherosclerosis

authors： Gary T,Belaj K,Hafner F,Hackl G,Froehlich H,Pilger E,Brodmann M

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND AND PURPOSES:Pulse wave analysis (PWV), a marker of aortic stiffness, has independent predictive value for cardiovascular morbidity and mortality in both healthy and high-risk populations, especially fatal stroke, and for long-term functional stroke prognosis. Whether arterial stiffness and wave reflection a...

journal_title：Atherosclerosis

authors： Gąsecki D,Rojek A,Kwarciany M,Kowalczyk K,Boutouyrie P,Nyka W,Laurent S,Narkiewicz K

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVE:Sulforaphane, a naturally occurring organosulfur compound in broccoli, has chemopreventive properties in cancer. However, the effects of sulforaphane in vascular diseases have not been examined. We therefore aimed to investigate the effects of sulforaphane on vascular smooth muscle cell (VSMC) proliferation a...

journal_title：Atherosclerosis

authors： Kwon JS,Joung H,Kim YS,Shim YS,Ahn Y,Jeong MH,Kee HJ

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Mutations in the LDL receptor gene are the major cause of familial hypercholesterolaemia (FH) but it has been previously shown that the simple finding of a variation in the coding sequence of the LDLR does not confirm that it is the actual cause of FH. The pathogenicity of five missense alterations in the LD...

journal_title：Atherosclerosis

authors： Silva S,Alves AC,Patel D,Malhó R,Soutar AK,Bourbon M

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:The complement system is involved in the pathogenic course of SLE. These patients exhibit metabolic disturbances in lipoprotein metabolism characterized by a pro-inflammatory status and an accelerated atherosclerosis. The aim of this study is to investigate whether levels of the complement are associated to ...

journal_title：Atherosclerosis

authors： Parra S,Vives G,Ferré R,González M,Guardiola M,Ribalta J,Castro A

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVES:Atherosclerosis is a chronic disease characterized by two main features, lipid retention and inflammation. The 12/15-lipoxygenases play a two-faced role in atherosclerosis with pro-inflammatory effects through oxidation of LDL and anti-inflammatory effects through lipid mediator synthesis. In cells involved ...

journal_title：Atherosclerosis

authors： Wuest SJ,Crucet M,Gemperle C,Loretz C,Hersberger M

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVE:To determine whether endogenous sex hormones (estradiol (E2), testosterone (T), sex hormone binding globulin (SHBG), and follicle stimulating hormone (FSH)) are longitudinally associated with progression of atherosclerosis among women at midlife. METHODS:249 Pre- or early peri-menopausal women (42-57 years) ...

journal_title：Atherosclerosis

authors： El Khoudary SR,Wildman RP,Matthews K,Thurston RC,Bromberger JT,Sutton-Tyrrell K

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVE:Intracranial atherosclerosis (ICAS) is a major cause of ischemic stroke; however it is rather neglected. Vessel wall visualization by high resolution magnetic resonance imaging (HRMRI) might provide more accurate information. METHODS:A total of 219 consecutive patients with acute ischemic stroke underwent MR...

journal_title：Atherosclerosis

authors： Kim YS,Lim SH,Oh KW,Kim JY,Koh SH,Kim J,Heo SH,Chang DI,Lee YJ,Kim HY

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVE:The apolipoprotein E mimetic peptide Ac-hE18A-NH(2), capable of reducing plasma cholesterol and possessing anti-inflammatory properties, was compared with the well-studied anti-atherogenic apoA-I mimetic peptide 4F for reducing lesion formation in female apoE null mice with already existing lesions. METHODS ...

journal_title：Atherosclerosis

authors： Nayyar G,Garber DW,Palgunachari MN,Monroe CE,Keenum TD,Handattu SP,Mishra VK,Anantharamaiah GM

更新日期：2012-10-01 00:00:00

abstract：:The pathogenesis of retinal vein occlusion (RVO), has not been well understood. Recent data have shown the efficacy of an anticoagulant therapy with LMWHs in the treatment of acute RVO suggesting the presence of a hypercoagulable state in these patients. New global tests for detection of hypercoagulability and hypofib...

journal_title：Atherosclerosis

authors： Cellai AP,Lami D,Fedi S,Marcucci R,Mannini L,Cenci C,Rogolino A,Sodi A,Menchini U,Abbate R,Prisco D

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVE:To investigate SCM-198 (also known as "leonurine"), a compound in Herba leonuri, as well as its effect on the progression of atherosclerosis in hypercholesterolemic rabbits and underlying mechanisms. METHODS:Thirty New Zealand male White rabbits (5 groups, n = 6) were fed either a normal diet or a high-chole...

journal_title：Atherosclerosis

authors： Zhang Y,Guo W,Wen Y,Xiong Q,Liu H,Wu J,Zou Y,Zhu Y

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:The identification of mutations in PCSK9 (proprotein convertase subtilisin kexin9) in autosomal dominant hypercholesterolemia (ADH), has revealed the existence of a new player in cholesterol homeostasis. PCSK9 has been shown to enhance the degradation of the LDL receptor (LDLR) at the cell surface. Gain-of-f...

journal_title：Atherosclerosis

authors： Abifadel M,Guerin M,Benjannet S,Rabès JP,Le Goff W,Julia Z,Hamelin J,Carreau V,Varret M,Bruckert E,Tosolini L,Meilhac O,Couvert P,Bonnefont-Rousselot D,Chapman J,Carrié A,Michel JB,Prat A,Seidah NG,Boileau C

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVE:The purpose of the study was to examine the prevalence and risk factors for cerebral infarction (CI) and carotid artery stenosis (CAS) in patients with peripheral arterial disease (PAD) compared with normal controls. METHOD:A cross-sectional analysis was performed in 857 subjects (PAD: 543, controls: 314). C...

journal_title：Atherosclerosis

authors： Araki Y,Kumakura H,Kanai H,Kasama S,Sumino H,Ichikawa A,Ito T,Iwasaki T,Takayama Y,Ichikawa S,Fujita K,Nakashima K,Minami K,Kurabayashi M

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVE:We investigated the separate impact of metabolic syndrome (MS) and altered glucose tolerance on early markers of vascular injuries. METHODS:Intima-media thickness (IMT) and pulse wave analysis (PWA), were evaluated in 132 overweight or obese subjects, with (MS(+)) or without (MS(-)) MS; subjects were further...

journal_title：Atherosclerosis

authors： Di Pino A,Alagona C,Piro S,Calanna S,Spadaro L,Palermo F,Urbano F,Purrello F,Rabuazzo AM

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVE:Apolipoprotein E (apoE) has been implicated as conveying increased risk for coronary artery disease (CAD). Previous studies suggest a role of apoE as a modulator of immune response and inflammatory properties. We hypothesized that the presence of apo E4 is associated with an increased inflammatory burden in s...

journal_title：Atherosclerosis

authors： Gungor Z,Anuurad E,Enkhmaa B,Zhang W,Kim K,Berglund L

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVE:The distribution of atherosclerotic lesions changes with age in human and rabbit aortas. We investigated if this can be explained by changes in patterns of blood flow and wall shear stress. METHODS:The luminal geometry of thoracic aortas from immature and mature rabbits was obtained by micro-CT of vascular c...

journal_title：Atherosclerosis

authors： Peiffer V,Rowland EM,Cremers SG,Weinberg PD,Sherwin SJ

更新日期：2012-07-01 00:00:00

abstract：:The lecithin:cholesterol acyltransferase (LCAT) enzyme is responsible for the synthesis of cholesteryl esters in human plasma and plays a critical role in high density lipoprotein (HDL) metabolism. Genetic LCAT deficiency is a rare metabolic disorder characterized by low HDL cholesterol levels. This paper reviews the ...

journal_title：Atherosclerosis

authors： Calabresi L,Simonelli S,Gomaraschi M,Franceschini G

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVES:We conducted a meta-analysis of relevant randomized trials to assess whether folic acid supplementation reduces the progression of atherosclerosis as measured by carotid intima-media thickness (CIMT). METHODS:This analysis included 2052 subjects from ten folic acid randomized trials with the change in CIMT ...

journal_title：Atherosclerosis

authors： Qin X,Xu M,Zhang Y,Li J,Xu X,Wang X,Xu X,Huo Y

更新日期：2012-06-01 00:00:00

abstract：AIMS:Transition metal ions have been implicated in atherosclerosis. The goal of this study was to investigate whether metal ion levels were higher in people with diabetes, in view of their increased risk of aggravated atherosclerosis. METHODS AND RESULTS:Absolute concentrations of iron, copper, zinc and calcium, and p...

journal_title：Atherosclerosis

authors： Stadler N,Heeneman S,Vöö S,Stanley N,Giles GI,Gang BP,Croft KD,Mori TA,Vacata V,Daemen MJ,Waltenberger J,Davies MJ

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVES:Inflammation may directly impair HDL functions, in particular reverse cholesterol transport (RCT), but limited data support this concept in humans. METHODS AND RESULTS:We employed low-dose human endotoxemia to assess the effects of inflammation on HDL and RCT-related parameters in vivo. Endotoxemia induced ...

journal_title：Atherosclerosis

authors： de la Llera Moya M,McGillicuddy FC,Hinkle CC,Byrne M,Joshi MR,Nguyen V,Tabita-Martinez J,Wolfe ML,Badellino K,Pruscino L,Mehta NN,Asztalos BF,Reilly MP

更新日期：2012-06-01 00:00:00